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Archaea, 2
© 2006 Heron Publishing—Victoria, Canada
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An analysis of amino acid sequences surrounding archaeal glycoprotein sequons

Mehtap Abu-Qarn (1) and Jerry Eichler (1, 2)

1. Department of Life Sciences, Ben Gurion University, Beersheva 84105, Israel / 2. Corresponding Author ([email protected]) / Received June 20, 2006; accepted July 26, 2006; published online July 31, 2006

Summary

Despite having provided the first example of a prokaryal glycoprotein, little is known of the rules governing the N-glycosylation process in Archaea. As in Eukarya and Bacteria, archaeal N-glycosylation takes place at the Asn residues of Asn-X-Ser/Thr sequons. Since not all sequons are utilized, it is clear that other factors, including the context in which a sequon exists, affect glycosylation efficiency. As yet, the contribution to N-glycosylation made by sequon-bordering residues and other related factors in Archaea remains unaddressed. In the following, the surroundings of Asn residues confirmed by experiment as modified were analyzed in an attempt to define sequence rules and requirements for archaeal N-glycosylation.

Keywords: Archaea, N-glycosylation, oligosaccharide transferase, post-translational modification.


 ISSN 1472-3654 (Online) ISSN 1472-3646 (Print) Copyright © 2002–2006 Heron Publishing